Background: In our previous genome-wide association study (GWAS) on the piglet splay leg (PSL) syndrome, the\nhomer scaffolding protein 1 (HOMER1) was detected as a candidate gene. The aim of this work was to further verify\nthe candidate gene by sequencing the gene and find the significantly associated mutation. Then we preliminarily\nanalyzed the effect of the significant SNP on intronic promoter activity. This research provided a reference for\nfurther investigation of the pathogenesis of PSL.\nResult: We investigated the 19 SNPs on HOMER1 and found 12 SNPs significant associated with PSL, including 8\nSNPs resided in the potential intronic promoter region in intron 4. The â?? 663â?¦â?¦â?¦â?¦
Loading....